Which bisphosphonate is listed as IV with a potency of 100?

Which bisphosphonate is listed as IV with a potency of 100?

• A. Etidronate
• B. Pamidronate
• C. Clodronate
• D. Tiludronate

Answer: (B)

Pamidronate is the intravenous bisphosphonate with a potency rating of 100 in the common comparative tables. The IV route is the hallmark here—pamidronate is administered intravenously to achieve rapid and high systemic exposure, which is important for conditions like hypercalcemia of malignancy or extensive bone resorption. Its potency value of 100 means it is 100 times more potent than the reference compound (etidronate, set at 1) in inhibiting osteoclast-mediated bone resorption. Other bisphosphonates on the list are either less potent or are typically given by non-IV routes, so they don’t meet both criteria together.

Pamidronate is the intravenous bisphosphonate with a potency rating of 100 in the common comparative tables. The IV route is the hallmark here—pamidronate is administered intravenously to achieve rapid and high systemic exposure, which is important for conditions like hypercalcemia of malignancy or extensive bone resorption. Its potency value of 100 means it is 100 times more potent than the reference compound (etidronate, set at 1) in inhibiting osteoclast-mediated bone resorption. Other bisphosphonates on the list are either less potent or are typically given by non-IV routes, so they don’t meet both criteria together.